Abstract
Author(s): Kavitha Siddoju1* and Jagadeesh Kumar Ega2
In this paper we would like to discuss the efficient synthesis of pyrazin fused N-(3-Mercapto-5-Aryl- [1,2,4]triazol-4-yl)-amide (5a-m and 6a-r) from4-Amino-5-Aryl-4H-[1,2,4]triazole-3-thiols(4a-b) through N-acylaton under dry dioxane, R1COCl, reflux, 10 h by a sequential manner probably the steps are mentioned in Scheme-1 ,Table-1,2. The structures of the compounds were elucidated by spectral (IR,1HNMR, 13CNMR and MS) analysis. The reactions are easy to conduct, under mild conditions, and form amide substituted triazole derivatives with excellent yields.