ISSN: 2249–9504
CAS CODEN: IJPCDX

SPECTROPHOTOMETRIC DETERMINATION OF TERBINAFINE HCL AND TELMISARTAN USING POTASSIUM PERMANGANATE

Abstract

Author(s): Afaf Abou-elkheir*, Hanaa M. Saleh, Magda M. El-henawee, Basma El-Sayed Ghareeb

Rapid, simple and validated spectrophotometric method has been described for the assay of Terbinafine HCl and Telmisartan either in pure form or in pharmaceutical formulations. The proposed method was based on the oxidation of the studied drugs by known concentration of potassium permanganate in alkaline medium, the increase in absorbance of coloured manganate ions was measured at 610 nm. Different variables affecting the reaction were studied and optimized. The calibration graphs were linear in the concentration ranges of 2-16µgml-1 and 40- 128µgml-1 for Terbinafine HCl and Telmisartan, respectively. The proposed method was applied successfully for determination of the examined drugs either in a pure or pharmaceutical dosage forms with good accuracy and precision. The results obtained were in good agreement with those obtained using the reference method.

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