ISSN: 2249–9504
CAS CODEN: IJPCDX

ROLE OF FREE RADICALS AND ANTIOXIDANTS IN SCHIZOPHRENIA

Abstract

Author(s): JayitaDasgupta (Ghosh)1, SambitDasgupta2*, Rajni3and RK. Singh

A disturbance in antioxidant defense system due to free radical induced oxidative injury has been implicated in various neuropsychiatric disorders. Increased generation of free radicals has been supposed to be one of the important causes of schizophrenia. To scrutinize our findings related to possible imbalance in redox status responsible for oxidative damage, parameters for both lipid peroxidation and antioxidant activity were selected and estimated. Blood samples were analysed for Malondialdehyde(MDA), Ascorbic acid and Superoxide dismutase( SOD). Serum TBARS (Thiobarbituric acid reacting substance) was selected as marker for free radical induced lipid peroxidationand plasma ascorbate and plasma SOD were selected as markers of antioxidant status. MDA is a secondary product of lipid peroxidation and our study showed a significant increase in free radicals incases compared to controls.Further a significant decrease in level of antioxidants Vitamin C and SOD were observed in schizophrenic patients compared to normal controls

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