ISSN: 2249–9504
CAS CODEN: IJPCDX

QUANTITATIVE ESTIMATION OF ATENOLOL INPHARMACEUTICAL OSAGE FORMS BY USING VISIBLESPECTROSCOPY

Abstract

Author(s): P. Madhurai, G. Raveendra Babu, P. Sambasiva Rao, B. Sivasai Kiran, M. Venkata Kumari

A literal and specific visible spectrophotometric method was raised for the estimation for atenolol in
solid pharmaceutical dosage form. Method was based on the formation of coloredchromogen (β-
napthol). The λ-max of atenolol was found to be 549nm to both crude and marketed sample and is
analyzed using Beer-Lamberts law. Beer’s law was obeyed at the concentrations ranging 2-
10μg/ml. The developed methods were absolute, definite, explicit and consistent and found to be
original type for routine determination for atenolol. The method was validated statistically and by
recovery studies. The LOD (limit of detection) and LOQ (limit of quantification) for visible spectra
were found to be 5.88μg/ml and17.83μg/ml. The correlation coefficient value was found to be
0.999. The purity was found to be 99.5%.

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