ISSN: 2249–9504
CAS CODEN: IJPCDX

PRODRUG DESIGN: AN OVERVIEW

Abstract

Author(s): Supriya Shirke*, Sheetal Shewale, Manik Satpute

The poor drug properties such as solubility, permeability, stability, toxicity, drug targeting are serious challenges for the successful development and commercialization of drug molecules and this is major reason only one out of ten clinically studied drug molecule reach to the market. Prodrug design is fruitful approach for drug targeting by changing the physiochemical, biopharmaceutical or pharmacokinetic properties.Prodrugs, are therapeutic active chemical agent, which must undergo transformation in vivo to release the active drug. About 10-14% drug approved worldwide can be classified as prodrugs. The present article takes a review of introduction, basic functional groups that are amenable to prodrugdesign, major applications of the prodrug strategy.

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