ISSN: 2249–9504
CAS CODEN: IJPCDX

PLANTAGO OVATA SEEDS AND BHRINGARAJ LEAVES AS SUPERDISINTEGRANTS: FORMULATION AND EVALUATION OF SOTALOL HYDROCHLORIDE ORODISPERSIBLE TABLETS

Abstract

Author(s): V. Sai Kishore*, B. Tejeswara Rao, K. Pavani, D. Nagasen, K. Rakesh Varma andD. Gowtham

other superdisintegrants natural origin is preferred because they are comparatively cheaper, abundantly available, non-irritatingand nontoxicin nature. An attempt has been made for the development of orodispersible tablets of theSotalol hydrochloride, using different concentrations of natural superdisintegrating agents likeplantago ovata mucilage, Bhringaraj powder, syntheticand semi synthetic superdisintegrants like cross povidone and croscarmellose sodium by direct compression method. Disintegration time and drug release were taken as the basis to optimize the orodispersible tablet. All the tablets were Prepared & evaluatedfor various parameters like hardness, weight variation, friability, thickness, disintegration time wetting time and dissolution time. Among all the formulations, formulation containing 5% w/w of natural superdisintegrant (Plantago ovata mucilage) was found to be shown faster and high drug dissolution.

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