ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

OPTIMIZATION OF THE PRODUCTION OF PROTEASE BY BACILLUS CEREUSWITH RESPONSE SURFACE METHODOLOGY USING GROUNDNUT SHELL

Abstract

Author(s): P.Rathakrishnan*and P.Nagarajan

The production of protease was optimized using groundnut shell as a substrate by Bacillus cereus. The nutrient variables were selected in accordance with the Plackett-Burman design. Four significant variables (NaNO3, Tryptone, K2HPO4and Malt extract) were selected for the optimization studies. The selected components were optimized using Response Surface Methodological approach. The optimum conditions are: NaNO30.0386g/gds,Tryptone0.0338g/gds,K2HPO40.2373g/gds and Malt extract 0.2090g/gds. A second-order model equation was suggested and then validated experimentally. The maximum protease production was 74.62U/gds.

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