ISSN: 2249–9504
CAS CODEN: IJPCDX

MICRO DETERMINATION OF PROMETHAZINE HYDROCHLORIDE DRUGS IN PURE FORM AND IN THEIR PHARMACEUTICAL PREPARATION WITH PYRIDINIUM FLUOROCHROMATE (PFC) REAGENT

Abstract

Author(s): Ajay Kumar Pandey* and Dharmendra Dwivedi

A simple visual titrimetric method have been described for the determination of Promethazine hydrochloride (PMH) in pure form and in its dosage forms.The principle of this method involves the oxidation of sulphur atom present in the Promethazine hydrochloride (PMH) to its corresponding sulphone compound by a known excess of potassium iodate in sulphuric acid medium followed by iodometric titration in presence of reagent pyridinium fluoro chromate (PFC). The stoichiometric ratio between the drug Promethazine hydrochloride (PMH) and Pyridinium fluorochromate has been found to be 1:1. The value of percentage error, coefficient of variation (CV) and standard deviation (SD) have been calculated for accuracy and precision of result.

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