ISSN: 2249-9504
CAS CODEN: IJPCDX

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Google Scholar citation report
Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

METHOD DEVELOPMENT AND VALIDATION OF DOXORUBICIN HCL IN API AND ITS FORMULATION BY SPECTROPHOTOMETRY

Abstract

Author(s): E.Manasa*, K. VanithaPrakash, P.RaviPratapand S.Susena

The article describes simple, economical, sensitive and accurate Spectrophotometric Method for the estimation of Doxorubicine hydrochloride,anti-cancer chemotherapy drug, in bulk and pharmaceutical dosage form. The developed Method was based on the formation complex of Doxorubicine hydrochloride with Bromo phenol blue chromogenic reagent. The colored chromogen shows maximum absorption at 420nm. The absorbance-concentration plot is linear over the range 5-60μg/ml. The correlation co-efficient was found to be 0.998. The different experimental parameters affecting the development and stability were studied carefully and optimized. A result of analysis for the method was validated statistically and recovery studies were also performed

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