Abstract
Author(s): Jain Nidhi, AK. Pathak
The objective of the present study was to investigate the hepatoprotectiveactivity of methanol extract of Cucurbita maxima Duchesne (Cucurbitaceae) (MECM)and Legenaria siceraria seeds against Paracetamol induced hepatotoxicity. Hepatoprotective activity was evaluated by the biochemicalestimation of liver function parameters (SGPT, SGOT), antioxidant assays of liver homogenate . In MECM treated animals, the toxic effect of paracetamol was controlled significantly by restoration of the biochemical parameters, such as, SGPT, SGOT,status to/towards near normal values. Histology of the liver sections of the animals treated with the extracts showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration, which further evidenced the hepatoprotective activity of C. maxima and L.siceraria methanol extract of the seeds aerial parts of C. maxima possesses significant hepatoprotective activity1-3.