Author(s): C. Haranath, J. Raveendra Reddy and N. Devanna
Cimetidine is histamine H2-receptor antagonist which is used to reduce the treatment of stomach ulcers. The drug has less bioavailability (60%) and lesser half life of 2 hours. The present work is concerned with the formulation and evaluation of floating tablets of Cimetidine using albizia gum in different proportions to enhance its bioavailability and prolonged residence time in stomach. Precompression parameters such as bulk density, tapped density, angle of repose, Hausner’s ratio were performed to all the formulations and were found to be in the acceptable limits which ensures the good flow properties. Post compression parameters such as weight variation, hardness, drug content, buoyancy studies and dissolution were performed to all the prepared formulations. The drug release kinetics revealed that the optimized formulation FCDA4 follows zero order kinetics and the mechanism was nonfickian.