Author(s): A.Seetha Devi, MD.Tabasum*, T.Harika,VL.Anusha, B.Viswanath and Sanikommu Baji Reddy
The aim of this work was preparation and evaluation of diclofenac sodium controlled release matrix tablets using various proportions of natural polymer Abelmoschus esculentusmucilage powder (i.e;Drug:Polymer ratio-1:0.25,1:0.5,1:1,1:1.5,1:2) as release controlling factor by Wet Granulation method. The tablets were evaluated for various parameters like friability, weight variation, hardness, drug time, content uniformity. In vitrodrug release characteristics of dosage form was evaluated in 6.8 pH phosphate buffer. All the formulations followed zero order kinetics along with diffusion mechanisms. From In vitrorelease data, formulation F4 containing Drug:Polymer (1:1.5) showedmaximum drug release of 99.8% . All the formulations F1 to F5 undergo Non-Fickian diffusion or Enomalous diffusion mechanism. Analysis of drug release rate from matrix system indicated drug was release by super case-II transport mechanism.