ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

FABRICATION & EVALUATION OF FLUOXETINE AND VITAMIN E FAST RELEASE BILAYER TABLETS IN DEPRESSION MANAGEMENT

Abstract

Author(s): Chitra Karthikeyini S*, Nalini G and Sachin Sundar N

The aim of the present research is fabrication of fluoxetine and Vitamin E fast release bilayer tablets. This investigation was carried out to achieve multi benefits in depression associated with sexual dysfunction problems .Objectives of this investigation are to wipes away the Depression immediately, to promotes the Fertility and sexual function in depressed patients and to scavenges the free radicals production on long term use. In this study both layers were formulated as immediate release layers with the aim of reaching high serum concentration in a short period of time. Direct compression method was used for formulation of fast release bilayer tablets. The optimized formulation consists of Fluoxetine and Vitamin E fast release layer. Vitamin E was taken as Tocopherol Succinate (tablet grade granules) .It is fat soluble drug. To make fast release of Vitamin E layer, polysorbate 80 (non-ionic surfactant) was added in 2% concentration. Like that half life of Fluoxetine is longer. So it is the suitable drug to formulate the fast release layer. Croscarmellose was used as the Superdisintegrant for fluoxetine and Vitamin E fast release layers. This Bilayer formulated tablets were evaluated for physico-chemical properties such as hardness, thickness, friability, weight variation and drug content uniformity. Invitro dissolution studies were carried out by using USP type II Paddle type apparatus. All the studies revealed that optimized bilayer tablets satisfy all the parameters and have the potency to meet the challenges of dose dependant side effect in depression and it provide quick onset of action in depression.

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