ISSN: 2249–9504
CAS CODEN: IJPCDX

EVALUATION OF HYPOLIPIDEMIC AND ANTI-OBESITY ACTIVITIES OF BIOPHYTUMSENSITIVUM LINN EXTRACTS ON HIGH FAT DIET INDUCED HYPERLIPIDEMIC RATS

Abstract

Author(s): Rajanikant T Kakade*, Nagesh Sandu, KL. Senthilkumar

Biophytum Sensitivum Linn., leaves and stems were extracted with Petroleum ether, Ethyl acetate and Methanol by successive hot extraction. All the extracts were evaluated for their in vitro hypolipidemic and anti-obesity effect in high fat diet induced rats. High fat diet treated animals have developed hyperlipidemia and obesity when compared with normal animals. Whereas MES and EAS significantly (p≤0.01) reduced the elevated levels of total cholesterol (TC), serum triglyceride (TG), LDL-cholesterol and VLDL- cholesterol, AST and ALT and elevate the decreased level of HDL-cholesterol. Other observations shows that rats treated with EAS & MES underwent a timedependent reduction in body weight. These results suggest that, EAS extracts possess good hypolipidemic and anti-obesity activity. EAS has more potential than MES because of high phenolic and flavonoid content.

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