ISSN: 2249–9504
CAS CODEN: IJPCDX

EVALUATION OF DRUG RELEASE RETARDANT POTENTIAL OFOCIMUM TENUIFLORUMLINN. SEED MUCILAGE ISOLATED BY DEFATTING METHOD

Abstract

Author(s): Meghana S. Kamble*, Satish D. Mendake, Pravin P. Aute, Rohini P. Chavan, Krunal K. Vaidya, Sandeep M. Dange, Kishor K. Bhalerao and Pravin D. Chaudhari

Sustained release dosage forms are advantageous as they reduce frequency of administration and side effects of drug and thus improve patient compliance. The present study aimed to evaluate the drug release retardant potential of Ocimum Tenuiflorum Linn seed mucilage isolated by defatting method. Diltiazem HCl a calcium channel blocker, freely water soluble drug having t1/23-5 h was selected and matrix tablet formulations were prepared. The release retardant polymer under study was used alone and in combination with povidone a commercially used release retardant polymer in 1:1 ratio. The matrix tablet formulations were evaluated for various parameters and in vitro drug release profile. The drug release kinetics profile from prepared formulations was compared with drug release profile of marketed sustained release formulation of diltiazem HCl. Out of seven formulations prepared F1, F3, F4, F5 were found to sustained drug release for more than 7 h. All the formulations except F6 and F7 showed extended drug release for more than 6 h. All the formulations when fitted to drug release kinetics showed Hixon-Crowel pattern. The seed mucilage of Ocimum Tenuiflorum Linn has shown good release retardant potential when used in combination with povidone

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