ISSN: 2249–9504
CAS CODEN: IJPCDX

EVALUATION OF ANTI ANXIETY ACTIVITY OF ETHANOLIC EXTRACT OF SapindusemarginatusFLOWERS IN EXPERIMENTAL ANIMAL MODELS

Abstract

Author(s): MejoChiratteparambilKorah*, JunaidRahmanPuthanvalappil, Sheik HajaSherief, VivekandanLalitha, SringaravelSengottuvelu and ThangavelSivakumar

The Anti anxiety activity of Ethanolic extract of Sapindusemarginatusflowers was determined by experimental animal models like Elevated plus maze, Despair swim test and Haloperidol induced catalepsy.The plant was collected in the month of March from Erode city and was extracted by Macceration using ethanol as solvent. The anxiolytic activity of the plant was studied using Diazepam (0.5mg/kg, i.p) as standard and with two different doses of extract (200mg/kg & 400mg/kg, Oral) by using elevated plus maze, despaire swim test and haloperidol induced catalepsy. The time spent by the test group in the open arm was found significant when compared to the standard in Elevated plus maze with both the doses of extract. The immobility time (reaction time) was significantly reduced in the test group when to compare to that of the standard in Despair swim test. The animals in the testgroup had a failure to correct an externally imposed unusual posture over a prolonged period of time in Catalepsy.The above studies have been concluded that the ethanolic extract of Sapindusemarginatusflowers exhibit anxiolytic effect in experimental rats. So it supports the use of Sapindusemarginatusflowers as anxiolytic agents. Further investigations should be made to elucidate the active constituent of responsible for the activity

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