ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

EFFICIENT AND SCALABLE SYNTHESIS OF N-(4-OXO-3-SUBSTITUTED2-SULFANYLIDENE IMIDAZOLIDIN-1-YL)-8-NITRONAPHTHO [2,1-B]FURAN-2-CARBOXAMIDE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITIES

Abstract

Author(s): KM. Nagarsha1, KP. Latha1 * , D. Ramesh2, MN. Kumaraswamy2 and DR. Ramesh3

The various substituted aromatic isothiocyanates in glacial acetic acid on treatment with 8- nitronaphtho[2,1-b]furan-2-carbohydrazide 4 afforded 2-(8-nitronaphtho[2,1-b]furan-2-carbonyl)-Nsubstituted)hydrazine-1-carbothioamides 5a-e. These on refluxing with chloroacetylchloride in DMF as a solvent yields N-(4-oxo-3-substituted-2-sulfanylideneimidazolidin-1-yl)8-nitronaphtho[2,1-b]furan-2- carboxamides 6 a-e. The structures of 5a-e and 6a-e have been established by spectral studies and they have been screened for antimicrobial activities

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