Abstract
Author(s): KM. Nagarsha1, KP. Latha1 * , D. Ramesh2, MN. Kumaraswamy2 and DR. Ramesh3
The various substituted aromatic isothiocyanates in glacial acetic acid on treatment with 8- nitronaphtho[2,1-b]furan-2-carbohydrazide 4 afforded 2-(8-nitronaphtho[2,1-b]furan-2-carbonyl)-Nsubstituted)hydrazine-1-carbothioamides 5a-e. These on refluxing with chloroacetylchloride in DMF as a solvent yields N-(4-oxo-3-substituted-2-sulfanylideneimidazolidin-1-yl)8-nitronaphtho[2,1-b]furan-2- carboxamides 6 a-e. The structures of 5a-e and 6a-e have been established by spectral studies and they have been screened for antimicrobial activities