ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

EFFECT OF SOLVENT AND CATALYSIS ON SYNTHESIS OF DIHYDROPYRIDINE DERIVATIVES

Abstract

Author(s): S. Baluja*and R. Talaviya

A facile and efficient preparation of dihydropyridine derivatives have been reported via a multi component reaction in the presence and absence of ammonium iron(II) sulphate. Further, synthesis is performed in different pure alcohols and their mixtures.A series of substituted dihydropyridine derivatives were synthesized and the structures of these compounds were established on the basis of spectral analysis. Excellent yield of compounds is observed in presence of ammonium iron(II) sulphate. Thus, ammonium iron(II) sulphate is proven to be a very efficient catalyst for synthesis of these derivatives. Further, among different alcohol mixtures, ethanol + isopropanol mixture gives higher yield and reaction time is also reduced.

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