Author(s): Kanekar PT*, Kamat SS, Das P, Subrahmanyam EVS and Shabaraya AR
Simple, sensitive, specific, and validated colorimetric methods have been developed for the quantitative estimation of Rabeprazole in bulk and pharmaceutical dosage form. Method A consists of redox reaction of Rabeprazole in presence of acidic medium reacts with excess amount of Cerric ammonium sulphate. The dye Safranin gave λmax of Rabeprazole at 516nm. Method B consist of redox reaction of Rabeprazole with ferric nitrate and the reduced ferrous ion than reacts with 1,10 Phenanthrolinegiving maximum absorbance at 511nm. The methods were validated as per ICH guidelines.