ISSN: 2249–9504
CAS CODEN: IJPCDX

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL BROMO-PYRIMIDINE ANALOGS AS ANTICANCER AND ANTIMICROBIAL AGENTS

Abstract

Author(s): GV. Suresh Kumar* and KA. Sridhar

A novel series of 5-bromo-pyrimidine derivatives (3,4,5a-l and 6a-h) were synthesized through multi step reactions starting from 5-bromo-2,4-dichloro pyrimidine. The newly synthesized compounds were characterized using elemental analysis and spectral data (IR, 1H NMR, 13C NMR and LC-MS) analysis. The titled compounds were evaluated for antimicrobial activity by broth dilution method and their in vitro cytotoxic activity. Among the synthesized compounds 5a, 5c, 5e, 6b, 6d, and 6h exhibit broad spectrum antimicrobial activity against tested microbial strains. The invitro cancer results ascertain 5c, 5e, 6d, 6g and 6h are most potent molecules in comparison to reference standard Dasatinib

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