ISSN: 2249–9504
CAS CODEN: IJPCDX

CALCULAT?ON OF AC?D D?SSOC?AT?ON CONSTANTS AND B?OLOG?CAL ACT?V?T?ES ?N SOME PYR?M?D?NE DER?VAT?VES AS KNOWN DRUG ACT?VE SUBSTANCE

Abstract

Author(s): Fatih ?slamo?lu*, Nesrin Karaali and Tolga Tanyel

Acid dissociation constants (pKa) of some pyrimidine derivatives were determined experimentally with potentiometric titration method. All compounds were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents (isopropyl alcohol, N,N-dimethyl formamide, tert-butyl alcohol and acetonitrile). Thus, the half-neutralization potential values and the corresponding pKa values were determined in all cases. In addition, pKa were determined theoretically with SPARC computer program. Pyrimidine derivatives have known different structures as drug active substance were evaluated for their biological activities such as antimicrobial activities.

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