ISSN: 2249–9504
CAS CODEN: IJPCDX

BIOLOGICAL EVALUATION AND VEGFR2 KINASE STUDIES OF METAL (II) COMPLEXES DERIVED FROM N-BENZOYLATEDTETRAZOLO[1,5-A]PYRIMIDINE LIGANDS WITH CIPROFLOXACIN DRUG

Abstract

Author(s): SH. Mohamed Yusuf1, Haleel Azees Khan1,2* and TK. Shabeer1

Ametal(II) mononuclear complexes of Cu(II) (1) & Zn(II) (2) holding tetrazole core ligand have been synthesized and described by spectral methods. The five coordinated square pyramidal geometry was determined by means of electronic absorption and EPR spectral methods. All the complexes exhibit significant antimicrobial activity against Gram (–ve) and Gram (+ve) bacterial as well as fungal strains, which were analyzedbyresazurin reduction assay.The complexes interact strongly with the receptor kinase VEGFR2 through the interaction of π-π, σ-π and hydrogen bonds, and form a stable complex through covalent interactions such as hydrophobic and van der Waals interactions and their binding energy values -24.04 (1) and -9.41 (2) kcal/mol for the complexes, respectively.

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