ISSN: 2249–9504
CAS CODEN: IJPCDX

ASSESSMENT OF ANTI DERMATOPHYTIC ACTIVITY OF ZINCODERM GM CREAM IN EXPERIMENTAL TINEA PEDIS IN WISTAR RAT

Abstract

Author(s): Satyam SM, Bairy KL, Musharaf S, Fernandes D, Prakash PY

Zincoderm GM cream is a fixed dose combination of clobetasol, gentamicin, miconazole and zinc.
Studies have been done for effica cy of each component like clobetasol, gentamicin and
miconazole but as fixed dose combination including Zinc has not been reported yet. Hence a
study was planned to assess the efficacy of Zincoderm GM cream in experimental Tinea pedis in
animal models. In the experiment a total of 24 Wistar rats (male, pathogen free, 6 8 weeks old)
were used. The rats were divided into 4 groups of 6 rats each. 25 30 mg of test drugs (Zincoderm
GM cream with or without Zinc) was applied on infected paws from 10th day of post infection.
Fungal infection was assessed by clinical response scoring system and fungal culture
examination. Clinical response (p<0.003) as well as fungal scores (p<0.001) was significantly
lower in Tinea pedis induced rats treated with Zincoderm GM cream with Zinc when compared to
Tinea pedis induced control (untreated) rats. There was no significant difference in clinical
response scores (P<0.0264) between Zincoderm GM with zinc and Zincod erm GM without zinc
treatment groups. However, there was significantly lower fungal score(P<0.019) in Tinea pedis
induced rats treated with Zincoderm GM cream with Zinc in comparison with Tinea pedis induced
rats treated with Zincoderm GM cream without Zin c.

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