Author(s): CHLVK. Prasad1*, K.Rama Rao1, M.Prasada Rao2, Venkateswarlu Guddeti3and T.Kala Praveen4
This study demonstrates the Anti-oxidant and Anti-inflammatory activity of ethyl acetate extract of the aerial parts of Argimone Mexicana. Inflammation was induced in mice by Croton oil induced ear edema, Croton oil induced capillary permeability and Cotton pellet granuloma pouch. Ethyl acetate extract of Argimone Mexicanawas found to be certain chemicals like alkaloids and fixed oils. The lethal dose (LD 50) selected was 2000 mg/kg body weight. Hence experimental doses were selected as 1/10 and 1/5 dose of Argimone Mexicanaextract. Anti-oxidant and Anti-inflammatory activity of ethyl acetate extract of the aerial parts of Argimone Mexicana was compared with standard anti-inflammatory agent Indomethacin. The present investigation revealed that, Argimone Mexicana exhibit statistically significant anti-oxidant activity and extract at low dose (200 mg/kg) and high dose (400 mg/kg). The results showed statically significant reduction in ear edema, capillary permeability and in granuloma. This activity may be due to the presence of alkaloids and fixed oils.