Abstract
Author(s): K. Madhuri, M. Senthil Kumar and L. Kalyani
Tinidazole, a synthetic nitroimidazole, a structural analogue of metronidazole, is an antiprotozoal agent that has been widely used for more than two decades with established efficacy and acceptable tolerability for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver abscess. Although oral delivery has become a widely accepted route of administration of therapeutic drugs, the gastrointestinal tract presents several formidable barriers to drug delivery. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon but also for its potential for the delivery of proteins and therapeutic peptides.