ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

A CATALYTIC METHOD FOR THE SYNTHESIS OF PYRAZOLONE DERIVATIVES USING HETEROPOLYACIDS AND STUDY OF THE ANTI-BACTERIAL ACTIVITY

Abstract

Author(s): Zaoui A1, Hammal l1, Bennamane N1, Merabtene S2and Nedjar-Kolli B1*

A series of pyrazolone derivative 3was synthesized by following two different procedures: The reaction of 3-acetyldihydrofuran-2(3H)-one 1and thiosemicarbazide derivatives 2 in ethanol without catalyst or from an efficient and improved procedure using Keggin-type heteropolyacid(HPAs). In this case excellent yields and short reaction times were obtained. The synthesizedcompounds 3were screened for their in vitro anti-bacterial activity against 4 bacterial strains

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